Table 1 Distribution of IDH1/2 mutations and cIMPACT-NOW 3 alterations in histological subgroups.

From: Optimizing the risk stratification of astrocytic tumors by applying the cIMPACT-NOW Update 3 signature: real-word single center experience

WHO (2016)

DA

AA

GBM

Overall

IDHwt

8

5

267

280

IDHmut

12

12

9

33

TERTpmut

7

6

237

250

EGFR amplification

4

2

105

111

Gain chromosome 7

13

14

147

174

Monosomy 10

8

5

196

209

PTEN deletion

0

3

16

19

 + 7/-10

2

4

116

122

  1. WHO, World Health Organization; DA, diffuse astrocytoma; AA, anaplastic astrocytoma; GBM glioblastoma; IDH, refers to both IDH1 and IDH2; wt, wild type; mut, mutation; + 7, multiple copies of chromosome 7; -10, monosomy 10.
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