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Figure 1

From: Unveiling gene regulatory networks during cellular state transitions without linkage across time points

Figure 1

Overview of the COSLIR method for reconstructing Gene Regulatory Networks (GRNs) using time-stamped cross-sectional single-cell expression data. (A) Depiction of time-stamped cross-sectional data generated in single-cell experiments. Only data within the solid red rectangles were measured. (B) Estimation of sample mean and covariance matrix. (C) Solving the optimization problem in COSLIR using ADMM. (D) Inferred gene regulatory network among the genes represented by the estimator \(\hat{A}\).

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