Figure 3 | Scientific Reports

Figure 3

From: Unveiling gene regulatory networks during cellular state transitions without linkage across time points

Figure 3

Overview of the analysis of real single-cell RT-PCR expression data using COSLIR. (A) Developmental lineage tree representing early mouse embryonic development. (B) Data visualization using Isomap. (C) Inferred gene regulatory networks (GRNs) directing ICM cells towards the EPI fate, accompanied by a corresponding sketch map. (D) Inferred GRNs directing ICM cells to the fate of PE, accompanied by its sketch map. (E, F) Early precision comparison of COSLIR with four existing algorithms during the two cell lineages: ICM cells towards the EPI fate (E) and the PE fate (F). Here, the clipping threshold is 0.01, the confidence threshold is 0.8, and the threshold of the rescaled values we chose is 0.25 for ICM to EPI and 0.1 for ICM to PE. More details can be found in Supplementary Figures S6–S7 and Table S5.

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