Figure 5

COSLIR being applied on single-cell Human blood atlas. (A) UMAP visualizations of human blood cell embeddings, with colors indicating distinct cell types. (B) COSLIR-inferred major upstream regulatory transcription factors (TFs) and downstream cell-type markers. (C) Time costs of different methods applied to subsampled atlases with varying cell numbers. (D) Time costs of COSLIR applied to subsampled atlases with different gene numbers. Further comprehensive verification with relevant literature can be found in Supplementary Tables S7–S10.