Figure 2

Root-mean square distance (RMSD) plot of the protein backbone. (A) Trans-(−)-kusunokinin in complex with CSF1R^W550A (red) or CSF1R^WT (black). (B) Trans-(+)-kusunokinin in complex with CSF1R^W550A (red) or CSF1R^WT (black). (C) Pexidartinib in complex with CSF1R^W550A (red) or CSF1R^WT (black). (D) Imatinib in complex with CSF1R^W550A (red) or CSF1R^WT (black). (E) Ligand-free CSF1R^W550A (red) or CSF1R^WT (black). The values were calculated from three independent simulation systems and represented as mean values.