Table 2 Comparison of clinical features and MRDQ and MVAQ scores between males, females with a male phenotype and females with a radial or focal pattern.

From: Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Variable

Males (M)

Females with male phenotype (FM)

Females with radial/focal pattern (FRF)

Overall

p-value

Pairwise comparison

p-value

M versus FM

FM versus FRF

M versus FRF

Age in years, median (IQR)

35.50 (26.00, 47.25)

59.00 (56.00, 62.00)

44.00 (31.00, 47.50)

0.115

–

–

–

BCVA of better-seeing eye in ETDRS letters, median (IQR)

67.00 (60.75, 72.00)

71.00 (70.00, 74.00)

85.00 (83.00, 85.00)

0.002*

0.4316

0.009*

0.003*

MRDQ theta scores, median (IQR)

 Central vision

0.312 (− 0.007, 0.995)

0.463 (− 0.343, 0.770)

− 0.894 (− 1.534, − 0.664)

0.004*

0.933

0.012*

0.008*

 Color vision

0.414 (− 0.097, 0.972)

− 0.026 (− 0.699, 0.640)

− 1.095 (− 1.348, − 0.842)

0.001*

0.295

0.035*

0.002*

 Contrast sensitivity

0.734 (0.358, 1.367)

0.519 (− 0.237, 0.836)

− 1.401 (− 1.401, − 0.862)

0.0001*

0.349

0.003*

0.0003*

 Scotopic function

0.859 (0.401, 1.133)

− 0.007 (− 0.225, 0.592)

− 1.172 (− 1.505, − 0.935)

< 0.0001*

0.053

0.004*

0.0001*

 Photopic peripheral function

0.798 (0.211, 1.399)

0.274 (− 0.060, 0.412)

− 1.262 (− 1.262, − 1.262)

< 0.0001*

0.138

0.016*

< 0.0001*

 Mesopic peripheral function

0.999 (0.259, 1.239)

0.014 (− 0.147, 0.496)

− 1.771 (− 1.771, − 1.159)

< 0.0001*

0.032*

0.004*

< 0.0001*

 Photosensitivity

0.048 (− 1.036, 0.520)

− 0.163 (− 0.634, − 0.084)

− 0.778 (− 1.093, − 0.527)

0.215

–

–

–

MVAQ theta scores, median (IQR)

 Rod-function anxiety

0.442 (− 0.003, 1.630)

0.180 (0.099, 0.881)

− 1.197 (− 1.197, − 0.415)

0.003*

0.835

0.014*

0.006*

 Cone-function anxiety

0.675 (0.207, 0.915)

0.442 (0.359, 0.689)

− 0.563 (− 0.861, − 0.243)

0.017*

0.780

0.022*

0.022*

  1. BCVA best corrected visual acuity, ETDRS early treatment of diabetic retinopathy study, IQR interquartile range, MRDQ Michigan retinal degeneration questionnaire, MVAQ Michigan vision-related anxiety questionnaire.
  2. Asterisk (*) indicate a significant value (adjusted p-value < 0.05).
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