Figure 1

Effect of PA on DSS-induced UC mice. (A) It is an experimental flow chart. (B) The body weight changes were calculated using initial body weight as a datum line, n = 5. (C) Histopathological scores of each group were evaluated. Score 1 indicating no disease; 4 indicating the most severe disease) of average scores based on the combination of clinical symptoms body weight, diarrhea, and fecal blood, n = 5. (D) This image shows the length of the colonic tissue and the size of the spleen in each group of mice. (E) The lengths of colons from each group of mice, n = 3. (F–I) The mRNA expression of four inflammatory indicators in the colorectal tissues of mice was detected using qRT-PCR. The results showed that the mRNA expression level of Il-1β, Il-6, Tnf-α, and Ccl5 was significantly decreased by PA treatment, n = 3. It is worth noting that (B, C) using Statistical analysis was performed by two-way ANOVA. Other experiments still assessed the significance of differences by between-group analysis of variance. *p < 0.05; **p < 0.01; ***p < 0.001 versus the Vehicle group; ^#p < 0.05; ^##p < 0.01; ^###p < 0.001 versus the DSS-treated group. Data were presented as mean ± S.E.M.