Table 2 Antimicrobial Resistance and clonal gene determinants.
Functionalities | Encoded genes |
|---|---|
Antimicrobial determinants | |
Antimicrobial Resistance Phenotypes | cipr, eryr, gents, methr, penr, tetr, clids, trim/sulps |
Aminoglycosides modifying enzymes | aph(3')-III (M26832), aac(6')-aph(2'') (M13771), ant(6)-Ia (AF330699) |
ßeta-lactams | blaZ, blaI, blaR |
methicillin resistance | mecA (NC_007168) |
Tetracycline | tet(K) (U38656) |
Trimethoprim | dfrG(AB205645) |
teicoplanin-associated operon | TcaA, TcaB, TcaB2, TcaR |
Fluoroquinolones and other antibiotic targets | gyrA, gyrB, inhA, fabI, Iso-tRNA, kasA, MurA, rho, S10p,S12p) |
Rifampicin resistance gene | rpoB, rpoC |
Efflux pump | BceA, BceB, NorA, sdrM |
Conferring Streptomycin resistance | gidB |
Protein altering cell wall charge conferring antibiotic resistance | GdpD, MprF, PgsA |
Regulator modulating expression of antibiotic resistance genes | BceR, BceS, LiaF, LiaR, LiaS |
Staphylococcus aureus subspp aureus plasmid replicon | rep_Saa6159) (CP002115.1) rep_pMW2 (NC005011) |
Chromosomal cassette replicon | repC_Cassette (AB037671), repC_pS0385-1(AM990993.1) |
Regulatory genes | |
Staphylococcal accessory regulator A | sarA |
Histidine protein kinase locus | saeS |
Sensor protein | vraS |
Accessory gene regulator allele I | agrI (total)*, agrB-I, agrC-I, agrD-I |
Haemolysin d | hld* |
Clonal characterization | |
Clonal complex | CC7, spa t091, SCCmec V (AB505629.1), SCCmec IV(AM292304.1) |
Glycerophosphoryl diester phosphodiesterase, associated with mecA | ugpQ |
Cassette chromosome recombinase genes | ccrAA, ccrAA, ccrC* |
MLST | ST789 |
Carbamate kinase | arc3 |
Shikimate dehydrogenase | aroE4 |
Glycerol kinase | glpF1 |
Guanylate kinase | gmk4 |
Phosphate acetytransferase | pta4 |
Triosephosphate isomerase | tpi6 |
Actyl coenzyme A acetyltransferase | yqiL3 |
