Figure 2 | Scientific Reports

Figure 2

From: Vitamin D3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice

Figure 2The alternative text for this image may have been generated using AI.

Vitamin D3 induces divergent responses in plasma PTH and increases FGF23 in both WT or Npt2a−/− mice. Measurements of plasma PTH and FGF23 were performed in WT and Npt2a−/− mice following 4 days of treatment with either vehicle or vitamin D3 (n = 6 per genotype). (a) In WT mice, vitamin D3 treatment led to a decrease in plasma PTH levels. (b) In Npt2a−/− mice, plasma PTH levels were lower and unchanged in response to vitamin D3 treatment. (c & d) FGF23 levels significantly increased in both genotypes in response to vitamin D3 treatment. Male mice were used in these studies. In addition to single data summary data are shown and are expressed as mean ± SEM and were analyzed by repeated-measures two-way ANOVA followed by Tukey’s multiple comparisons test. *P < 0.05 vs WT same time point, #P < 0.05 vs baseline same genotype, §P < 0.05 vs vehicle same genotype and time point.

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