Figure 4 | Scientific Reports

Figure 4

From: Vitamin D3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice

Figure 4The alternative text for this image may have been generated using AI.

Similar effects of acute oral Pi loading on plasma Pi levels between genotypes. Plasma Pi levels were measured in WT and Npt2a−/− mice before and one hour after oral Pi loading via gavage (0.5 mol*L−1, 1% of body weight). These measurements were performed following 4 days of treatment with either a vehicle or vitamin D3 (n = 6 per genotype). (a & b) Oral Pi loading significantly increased plasma Pi levels independent of genotype or treatment; however, in vitamin D3-treated mice the increase was significantly greater compared to vehicle-treated mice. Male mice were used in these studies. In addition to single data summary data are shown and are expressed as mean ± SEM and were analyzed by repeated-measures two-way ANOVA followed by Tukey’s multiple comparisons test. *P < 0.05 vs WT same time point, #P < 0.05 vs baseline same genotype, §P < 0.05 vs vehicle same genotype and time point.

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