Table 1 Demographic data of patients with ESRD and UTUC in three groups.

	Unilateral RNU (N = 413)		Sequential unilateral RNU (N = 99)		Bilateral RNU (N = 64)		p-value
Mean age (SD)	65.2 (10.5)		66.0 (9.3)		62.6 (12.6)
Median follow up period in month (range)	45.1 (16.5–81.8)		47.3 (27.9–82.4)		43.1 (17.7–89.6)		0.716
	n	%	n	%	n	%
Gender
Male	123	29.8	42	42.4	20	31.3	0.005*
Female	290	70.2	57	57.6	44	68.8
ECOG
0	127	38.4	36	42.4	23	46.0	0.846
1	151	45.6	40	47.1	20	40.0
2	47	14.2	8	9.4	6	12.0
3	3	0.9	1	1.2	1	2.0
4	3	0.9	0	0.0	0	0.0
Smoking
No	382	92.5	86	86.9	56	88.9	0.168
Yes	31	7.5	13	13.1	7	11.1
Frequent chemical exposure
No	408	98.8	93	93.9	63	100.0	0.003**
Yes	5	1.2	6	6.1	0	0.0
Herbal supplements
No	363	87.9	92	92.9	55	87.3	0.340
Yes	50	12.1	7	7.1	8	12.7
Arsenic water intake
No	400	96.9	94	94.9	61	96.8	0.644
Yes	13	3.1	5	5.1	2	3.2
NA	0		0		1
Frequent hair-dying
no	410	99.3	97	98.0	61	96.8	0.186
yes	3	0.7	2	2.0	2	3.2
Coronary artery disease
No	376	91.0	88	88.9	58	90.6	0.804
Yes	37	9.0	11	11.1	6	9.4
Arrythmia
No	398	96.4	96	97.0	62	96.9	0.945
Yes	15	3.6	3	3.0	2	3.1
Hypertension
No	200	48.4	42	42.4	36	56.3	0.224
Yes	213	51.6	57	57.6	28	43.8
Diabetes mellitus
No	345	83.5	79	79.8	54	84.4	0.641
Yes	68	16.5	20	20.2	10	15.6
Gout
No	395	95.6	93	93.9	62	96.9	0.651
Yes	18	4.4	6	6.1	2	3.1
Other malignancies
No	352	85.2	84	84.8	52	81.3	0.712
Yes	61	14.8	15	15.2	12	18.8

ECOG Eastern Cooperative Oncology Group, ESRD end stage renal disease, RNU radical nephroureterctomy, SD standard deviation, UTUC upper tract urothelial carcinoma.
*p < 0.05, **p < 0.005.

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