Figure 3

Eriodictyol inhibits IL-1β-induced MMP1 and MMP3 production. Chondrocytes were pretreated with eriodictyol (5, 10, 15 μM) 12 h before IL-1β (10 ng/ml) treatment. 24 h after IL-1β treatment, the supernatants were collected. MMP1 and MMP3 levels in the supernatants were tested by the detection kits. The data presented are the means ± SEM of three independent experiments. #p < 0.01 versus control group; **p < 0.01 versus IL-1β group.