Figure 1 | Scientific Reports

Figure 1

From: Genetic association of lipid and lipid-lowering drug target genes with atopic dermatitis: a drug target Mendelian randomization study

Figure 1

Detailed flow chart of the study. Assumption 1: genetic variation should be strongly associated with the exposure of interest; Assumption 2: the genetic variants used as instruments should be independent of confounding factors that may influence the relationship between the exposure and the outcome; Assumption 3: the genetic variants should only affect the outcome through their impact on the exposure of interest. Abbreviations: PCSK9, proprotein convertase subtilisin/kexin type 9; GWAS, genome-wide association study; NPC1L1, Niemann-Pick C1-like protein 1; GLGC, Global Lipids Genetics Consortium; TC, total cholesterol; APOB, Apolipoprotein B-100; TG, triglyceride; LPL, lipoprotein lipase; LDL-C, low-density lipoprotein cholesterol; BBJ, Biobank of Japan; AD, atopic dermatitis; HMGCR, HMG-CoA reductase; ANGPTL3, angiopoietin-like 3; PPARA, Peroxisome Proliferator Activated Receptor Alpha; LDLR, LDL Receptor; APOC3, Apolipoprotein C-III. pQTL: Protein quantitative trait loci.

Back to article page