Table 1 MR analysis of the causal relationship between genetically proxied atopic dermatitis and lipid reduction.
Lipid trait | Methods | Training cohort (UKB) | Validation cohort (FinnGen) | Development cohort (BBJ) | |||
|---|---|---|---|---|---|---|---|
OR (95% CI) | p-Value | OR (95%CI) | p-Value | OR (95% CI) | p-Value | ||
LDL-lowing | MRpresso | 1.06 [0.91;1.24] | 0.431 | 0.96 [0.87;1.05] | 0.361 | 1.00 [0.87;1.15] | 0.996 |
MR Egger | 1.06 [0.86;1.32] | 0.577 | 1.00 [0.87;1.15] | 0.982 | 0.95 [0.76;1.20] | 0.688 | |
Weighted median | 1.04 [0.82;1.34] | 0.733 | 1.03 [0.91;1.16] | 0.630 | 1.02 [0.82;1.27] | 0.846 | |
Inverse variance weighted | 0.94 [0.81;1.10] | 0.430 | 0.96 [0.87;1.05] | 0.360 | 1.00 [0.87;1.16] | 0.996 | |
Weighted mode | 1.00 [0.79;1.28] | 0.972 | 0.99 [0.87;1.13] | 0.905 | 1.04 [0.84;1.30] | 0.695 | |
TG-lowing | MRpresso | 0.97 [0.82;1.16] | 0.750 | 0.93 [0.84;1.02] | 0.143 | 0.96 [0.86;1.06] | 0.994 |
MR Egger | 1.19 [0.89;1.57] | 0.238 | 0.88 [0.76;1.03] | 0.117 | 1.14 [0.88;1.49] | 0.333 | |
Weighted median | 1.20 [0.91;1.57] | 0.192 | 0.89 [0.77;1.03] | 0.116 | 1.06 [0.85;1.32] | 0.592 | |
Inverse variance weighted | 1.02 [0.86;1.22] | 0.750 | 0.93 [0.84;1.02] | 0.143 | 1.04 [0.89;1.22] | 0.600 | |
Weighted mode | 1.28 [0.95;1.71] | 0.102 | 0.90 [0.78;1.05] | 0.178 | 1.06 [0.85;1.33] | 0.609 | |
TC-lowing | MRpresso | 0.97 [0.83;1.13] | 0.665 | 0.98 [0.91;1.07] | 0.665 | 1.01 [0.87;1.17] | 0.893 |
MR Egger | 1.24 [0.97;1.58] | 0.086 | 0.96 [0.85;1.08] | 0.466 | 1.20 [0.93;1.54] | 0.163 | |
Weighted median | 1.12 [0.89;1.40] | 0.331 | 1.03 [0.92;1.15] | 0.582 | 1.05 [0.85;1.30] | 0.636 | |
Inverse variance weighted | 1.03 [0.89;1.21] | 0.665 | 0.98 [0.91;1.07] | 0.665 | 0.99 [0.86;1.14] | 0.892 | |
Weighted mode | 1.21 [0.92;1.59] | 0.165 | 0.98 [0.87;1.11] | 0.787 | 1.11 [0.89;1.38] | 0.355 | |
