Figure 4 | Scientific Reports

Figure 4

From: LincRNA-p21/AIF-1/CMPK2/NLRP3 pathway promoted inflammation, autophagy and apoptosis of human tubular epithelial cell induced by urate via exosomes

Figure 4

LincRNA-p21 contributed to inflammation, autophagy and apoptosis of HK2 cells cultured with urate. (A) The expression of lincRNA-p21 in HK2 cells was detected by qPCR. (B) The apoptosis of HK2 cells was detected by Annexin V-FITC/PI. (C and D) The expression of AIF-1, CMPK2, NLRP3, p53, p62, and LC3BII/I in HK2 cells were detected by western blot. (E and F) The expression of AIF-1, CMPK2, NLRP3, p53, p62, and LC3BII/I in exosome were detected by western blot. Versus normal control group, *p < 0.05, **p < 0.01, ***p < 0.001.

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