Table 3 Beta coefficients and 95% confidence intervals of Life’s Essential 8 for cognitive tests scores.

	CERAD: Delayed Recall Score						CERAD: Total Score (3 Recall trials)						Animal Fluency: Total Score						Digit Symbol: Score
	Beta		95% CI¹		p-value		Beta		95% CI¹		p-value		Beta	95% CI¹		p-value			Beta		95% CI¹		p-value
Life’s Essential 8
No-adjusted		0.02		0.01, 0.03		< 0.001		0.04		0.02, 0.06		< 0.001			0.09		0.05, 0.12	< 0.001		0.29		0.18, 0.41		< 0.001
Age-adjusted		0.02		0.01, 0.02		< 0.001		0.04		0.03, 0.06		< 0.001			0.09		0.06, 0.12	< 0.001		0.3		0.20, 0.40		< 0.001
Fully adjusted²	0.01		0.00, 0.02		0.052		0.02		0.00, 0.04		0.035		0.04	0.01, 0.07		0.007			0.11		0.02, 0.19		0.015
CVH status (Based on Life’s Essential 8)
No adjusted
Low CVH (0–49 points)	Reference						Reference						Reference						Reference
Moderate CVH (50–79 points)	0.26		0.00, 0.52		0.048		0.59		− 0.06, 1.2		0.076		1.6	0.65, 2.5		0.002			6		2.2, 9.9		0.003
High CVH (80–100 points)	0.82		0.40, 1.2		< 0.001		1.9		1.1, 2.8		< 0.001		3.5	2.0, 5.1		< 0.001			12		7.0, 17		< 0.001
Age-adjusted
Low CVH (0–49 points)	Reference						Reference						Reference						Reference
Moderate CVH (50–79 points)	0.42		0.13, 0.71		0.007		0.9		0.32, 1.5		0.004		1.9	1.0, 2.8		< 0.001			7.5		4.1, 11		< 0.001
High CVH (80–100 points)	0.95		0.56, 1.3		< 0.001		2.2		1.3, 3.1		< 0.001		3.8	2.4, 5.2		< 0.001			13		9.0, 17		< 0.001
Fully adjusted²
Low CVH (0–49 points)	Reference						Reference						Reference						Reference
Moderate CVH (50–79 points)	0.19		− 0.17, 0.55		0.3		0.33		− 0.35, 1.0		0.3		0.94	0.14, 1.7		0.025			2.9		0.41, 5.3		0.025
High CVH (80–100 points)	0.51		0.08, 0.95		0.022		1.1		0.11, 2.1		0.031		1.7	0.41, 3.1		0.014			4.5		0.56, 8.5		0.028

¹CI = Confidence Interval; CVH, cardiovascular health; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease.
²Fully adjusted: adjusted for age, sex, race, education level, ratio of family income to poverty and alcohol consumption.
Significant values are in bold.

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