Table 4 Univariate and multivariate analyses of factors associated with acute kidney injury within 48 h after intensive care unit admission.
Univariate | Multivariate* | |||
|---|---|---|---|---|
Crude OR (95% CI) | p | Adjusted OR (95% CI) | p | |
Age | 1.01 (0.99–1.02) | 0.556 | ||
Male gender | 0.79 (0.46–1.34) | 0.380 | ||
Body mass index | 1.03 (0.97–1.08) | 0.359 | ||
Hypertension | 1.58 (0.96–2.62) | 0.074 | 2.03 (1.03–3.99) | 0.040 |
Diabetic mellitus | 1.23 (0.71–2.12) | 0.456 | ||
Heart failure | 2.12 (1.03–4.34) | 0.041 | ||
Cirrhosis | 0.90 (0.34–2.41) | 0.838 | ||
Malignancy (solid tumor) | 0.68 (0.40–1.15) | 0.149 | ||
ACEi/ARB exposure | 1.75 (0.97–3.14) | 0.061 | ||
Diuretic exposure | 1.72 (0.89–3.34) | 0.108 | ||
Contrast exposure | 0.74 (0.42–1.31) | 0.303 | ||
Nephrotoxic agent exposure | 2.72 (1.07–6.95) | 0.037 | 4.49 (1.24–16.19) | 0.022 |
Indication for ICU admission | ||||
Pneumonia | 1.01 (0.58–1.78) | 0.968 | ||
Sepsis | 1.06 (0.52–2.14) | 0.874 | ||
Acute heart failure | 0.28 (0.03–2.24) | 0.228 | ||
Massive bleeding | 0.40 (0.09–1.84) | 0.239 | ||
Disease severity | ||||
APACHE II scores | 1.06 (1.02–1.09) | 0.001 | ||
SOFA scores | 1.23 (1.13–1.34) | < 0.001 | 1.18 (1.06–1.31) | 0.003 |
Ventilator usage | 2.03 (0.43–9.58) | 0.373 | ||
Inotrope/vasopressor usage | 1.54 (0.92–2.57) | 0.100 | ||
Mean arterial pressure (mmHg) | 0.98 (0.96–1.00) | 0.083 | ||
White blood cells (K) | 1.02 (0.99–1.04) | 0.169 | ||
Hemoglobin (mg/dL) | 0.94 (0.83–1.07) | 0.330 | ||
Initial eGFR (mL/min /1.73 m2) | 0.98 (0.98–0.99) | < 0.001 | 0.99 (0.98–1.00) | 0.007 |
Proteinuria | 2.38 (1.25–4.53) | 0.009 | ||
Glucose (mg/dL) | 1.00 (0.99–1.00) | 0.025 | 0.99 (0.99–1.00) | 0.006 |
Lactate (mg/dL) | 1.01 (1.00–1.02) | 0.082 | ||
NT-pro-BNP (pg/mL) | 1.00 (1.00–1.00) | 0.045 | ||
High corin (≥ 910 pg/mL) | 3.43 (2.00–5.88) | < 0.001 | 2.15 (1.11–4.19) | 0.024 |
