Fig. 4
From: Insights into aging mechanisms from comparative genomics in orange and silver roughies
Protein sequence comparison and homology modelling of SIRT1. (A) Partial amino acid sequence alignment of Hoplostethus and other fish, vertebrate and invertebrate species; position p.412 is highlighted. This position is also represented in a protein model of SIRT1 from (B) H. mediterraneus; (C) H. atlanticus; and (D) a human model with interaction with resveratrol84. The dashed blue lines indicate H-bonds, whereas the dashed purple line indicates steric clashes.
