Fig. 8
From: Bovine lactoferrin inhibits Plasmodium berghei growth by binding to heme
Docking simulation of heme and various transferrin family (bLF, OTf, and hLF). (a) Top 5 predicted binding poses of bLF (PDB: 1BLF) to heme, showing the C-1a region in red. (b, c) Magnified view of the two poses that bind to the C-1a region, with the amino acids interacting with the ligand on the right and the region's surface where the ligand interacts with the receptor on the bottom. Top 5 poses predicted to bind heme and (d) OTf (PDB:1OVT, 1AIV), or (e) hLF (PDB:1LFG, 1CB6), and C-1a homology regions are shown in red. (f) Multiple sequence alignment of the C-1a region among bLF, hLF, OTf, and bTF. The analysis reveals high sequence similarity, indicating a structurally conserved region, suggesting that transferrins possessing the C-1a region have the potential to bind heme.
