Table 5 Comparison of Outcome in Blood Level of Growth Factors between the Diabetic Groups.

From: Effect of polydeoxyribonucleotide and polynucleotide on rotator cuff healing and fatty infiltration in a diabetic rat model

 

Normal Vs DM (G1 vs G2)

G1 vs G2

VEGF (2nd OP)

25.5 ± 1.9 Vs 23.9 ± 2.7

(−1.1–4.3)

0.212

VEGF (2nd injection)

23.1 ± 2.4 Vs 23.9 ± 2.3

(−3.5–1.9)

0.522

VEGF (sacrifice)

27.6 ± 2.2 Vs 26.6 ± 2.7

(−1.8–3.9)

0.456

FGF (2nd OP)

1149.7 ± 324.0 Vs 991.2 ± 267.4

(−187.5–504.4)

0.338

FGF (2nd injection)

840.1 ± 228.5 Vs 839.6 ± 161.8

(−230.1–231.0)

0.848

FGF (sacrifice)

1150.7 ± 187.4 Vs 982.5 ± 216.5

(−67.6–404.0)

0.146

IGF (2nd OP)

347.0 ± 70.8 Vs 323.7 ± 70.6

(−59.1–105.6)

0.655

IGF (2nd injection)

369.6 ± 16.3 Vs 273.2 ± 20.4

(75.0–117.9)

 < 0.001

IGF (sacrifice)

379.4 ± 9.0 Vs 239.0 ± 56.9

(87.7–193.1)

0.002

One−way ANOVA or Kruskal–Wallis testing

P < 0.05

Among DM (G2 ~ 4)

VEGF (sacrifice)

P = 0.002

G 2 Vs G 3

26.6 ± 2.7 Vs 28.8 ± 2.6

(−5.2–0.9)

0.048

G 2 Vs G 4

26.6 ± 2.7 Vs 39.1 ± 39.1 ± 7.7

(−19.7–(−5.3))

0.004

G 3 Vs G 4

28.8 ± 2.6 Vs 39.1 ± 7.7

(−17.5–(−3.2))

0.006

FGF (2nd injection)

P = 0.005

G 2 Vs G 3

839.6 ± 161.8 Vs 1161.4 ± 197.8

(−532.2–(−111.4))

0.007

G 2 Vs G 4

839.6 ± 161.8 Vs 897.1 ± 146.1

(−237.0–122.0)

1.000

G 3 Vs G 4

1161.4 ± 197.8 Vs 897.1 ± 146.1

(61.8–466.8)

0.028

FGF (sacrifice)

P = 0.006

G 2 Vs G 3

982.5 ± 216.5 Vs 1164.8 ± 210.7

(−431.2–66.4)

0.723

G 2 Vs G 4

982.5 ± 216.5 Vs 1532.4 ± 382.2

(−911.7–(−188.2))

0.005

G 3 Vs G 4

1164.8 ± 210.7 Vs 1532.4 ± 382.2

(−727–(−8.2))

0.075

  1. G1: Saline + Repair, G2: Saline + Repair, G3: PDRN + Repair, G4: PN + Repair, G: group, G1: normal, G2-4: DM, P < 0.05. OP: operation. One-way analysis of variance, followed by Bonferroni post hoc testing or Kruskal–Wallis analysis, followed by Mann–Whitney post hoc testing was used to analyze the values among the groups according to normality. The data of blood levels of growths factors were presented as mean ± standard deviation Vs mean ± standard deviation (95% confidence intervals) and p values. VEGF and FGF: pg/mL, IGF: ng/mL.