Table 1 Study participants characteristics.
Characteristic | Global | Remitters | Non-remitters | p-value* |
|---|---|---|---|---|
(N = 16) | (N = 8) | (N = 8) | ||
Distribution | ||||
Age—years | 9.1 ± 4.2 | 11.7 ± 2.8 | 6.5 ± 3.8 | 0.009† |
Sex—Male no. (%) | 7 (44) | 5 (63) | 2 (25) | 0.3‡ |
Pubertal—no. (%) | 7 (44) | 2 (25) | 5 (62.5) | 0.3‡ |
BMI (Z-score) | − 0.92 ± 1.22 | − 0.81 ± 1.43 | − 1.04 ± 1.01 | 0.65† |
Baseline diabetes characteristics | ||||
HbA1C—% [mmol/mol] | 12.2 ± 1.6 | 12.2 ± 2.0 | 12.1 ± 1.3 | 0.88† |
Presence of ketoacidosis—no. (%) | 5 (31) | 1 (13) | 4 (50) | 0.28‡ |
Glycaemia—mg/dL | 404 ± 162 | 405 ± 199 | 404 ± 136 | 0.99† |
Insulin administration | ||||
MDI—no. (%) | 11 (70) | 8 (100) | 3 (37.5) | 0.2‡ |
Glycemic control|| (n = 16) | ||||
HbA1C—% [mmol/mol] | 6.3 ± 1.0 | 5.5 ± 0.4 | 7.2 ± 0.7 | < 0.001† |
Insulin doses—IU/kg/day | 0.6 ± 0.4 | 0.4 ± 0.2 | 0.8 ± 0.5 | 0.07† |
IDAA1C | 8.8 ± 2.0 | 7.2 ± 0.6 | 10.4 ± 1.6 | 0.006† |
Fasting and stimulated C-peptide|| | ||||
CPEPBASAL (pmol/mL) | 0.2 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.1 | 0.1¶ |
CPEPSTIM (pmol/mL/min) | 0.5 ± 0.2 | 0.7 ± 0.5 | 0.3 ± 0.2 | 0.14¶ |
CPEPEST (pmol/mL)§ | 0.5 ± 0.2 | 0.6 ± 0.2 | 0.3 ± 0.1 | 0.01† |
Miss values—CPEPEST/CPEPSTIM (n) | 2/3 | 1/2 | 1/1 | / |