Table 1 Study participants characteristics.

From: Plasma proteomics in children with new-onset type 1 diabetes identifies new potential biomarkers of partial remission

Characteristic

Global

Remitters

Non-remitters

p-value*

(N = 16)

(N = 8)

(N = 8)

 

Distribution

 Age—years

9.1 ± 4.2

11.7 ± 2.8

6.5 ± 3.8

0.009

 Sex—Male no. (%)

7 (44)

5 (63)

2 (25)

0.3

 Pubertal—no. (%)

7 (44)

2 (25)

5 (62.5)

0.3

 BMI (Z-score)

− 0.92 ± 1.22

− 0.81 ± 1.43

− 1.04 ± 1.01

0.65

Baseline diabetes characteristics

 HbA1C—% [mmol/mol]

12.2 ± 1.6

12.2 ± 2.0

12.1 ± 1.3

0.88

 Presence of ketoacidosis—no. (%)

5 (31)

1 (13)

4 (50)

0.28

 Glycaemia—mg/dL

404 ± 162

405 ± 199

404 ± 136

0.99

Insulin administration

 MDI—no. (%)

11 (70)

8 (100)

3 (37.5)

0.2

Glycemic control|| (n = 16)

 HbA1C—% [mmol/mol]

6.3 ± 1.0

5.5 ± 0.4

7.2 ± 0.7

 < 0.001

 Insulin doses—IU/kg/day

0.6 ± 0.4

0.4 ± 0.2

0.8 ± 0.5

0.07

 IDAA1C

8.8 ± 2.0

7.2 ± 0.6

10.4 ± 1.6

0.006

Fasting and stimulated C-peptide||

 CPEPBASAL (pmol/mL)

0.2 ± 0.2

0.3 ± 0.2

0.2 ± 0.1

0.1

 CPEPSTIM (pmol/mL/min)

0.5 ± 0.2

0.7 ± 0.5

0.3 ± 0.2

0.14

 CPEPEST (pmol/mL)§

0.5 ± 0.2

0.6 ± 0.2

0.3 ± 0.1

0.01

 Miss values—CPEPEST/CPEPSTIM (n)

2/3

1/2

1/1

/

  1. HbA1C Glycated hemoglobin level, IDAA1C insulin dose-adjusted A1C, MDI multiple daily injection, NA not applicable.
  2. Plus–minus values are means ± SD. Percentages may not total to 100 because of rounding. *p-value calculated between remitters and non-remitters group. Results were considered as significant when under 0.05. Student t-test, Chi-square, ||Parameters evaluated at + 3 months after diagnosis, Wilcoxon-test §calculated as described by Wentworth et al.46.