Fig. 2
Coherent NMDAR antagonist HFO in the OB and aPC after MK801 injection in freely moving rats. (A) Examples of 130–180 Hz band-pass filtered signals and the corresponding raw LFPs recorded simultaneously from the OB and aPC after 0.15 mg/kg MK801 (please note the same scale for all signals). (B) Mean power spectra (N = 16 rats) of monopolar LFPs recorded from the OB and aPC analyzed for 60 s at baseline (BL) and 29–30 min post systemic injection of MK801. Insert, shows the bipolar-derived signal for the same data. (C) Comparison of HFO power in the OB and aPC post systemic injection of MK801, p = 0.0009, Wilcoxon matched-pairs test. (D) Group mean values of HFO in the OB and aPC post MK801 showing a positive correlation and Spearman rank values for the individual rats. Averages were computed from 60 windows (30 seconds each) totaling 1800 seconds (30 minutes) post MK801 i.p. (E) Coherence spectra calculated at baseline and post MK801. The adjacent plot shows the maximum coherence for the 130–180 Hz band at baseline and after MK801 for each rat (p < 0.001, paired t-test). F1, Representative comodulograms post MK801 showing slow oscillations (1–10 Hz) can modulate the 130–180 Hz band recorded locally in the OB and PC. The third example shows slow oscillations in the OB (1–10 Hz) can modulate 130–180 Hz band in the PC. F2, Modulation indices for individual rats at baseline and post MK801, p < 0.0001 for the OB), p = 0.004 for the PC, p = 0.0002 for the OB-PC (paired t-tests).
