Table 1 Characteristics of the experimental models of infection and associated mortality and weight loss.
From: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies
Infectious agent | Experiments (n) | Mice (n) | Inoculum, median CFU/PFU [IQR] | Non-survivors (n) | Mortality rate (%) | Median time to death (days) | Median time to death of non-survivors (days) | Mice with > 30% weight loss (n) | Survivors with > 30% weight loss (n) |
|---|---|---|---|---|---|---|---|---|---|
C. albicans | 6 | 252 | 1.6 × 105 [0.8–2 × 105] | 88 | 34.9 | n.a | 8 | 64 | 16 |
L. monocytogenes | 39 | 1′048 | 1.2 × 105 [0.9–1.6 × 105] | 493 | 47.0 | n.a | 4 | 8 | 5 |
S. pneumoniae | 32 | 721 | 5.8 × 104 [0.2–2.9 × 105] | 393 | 54.5 | 9 | 5 | 2 | 1 |
H1N1 | 19 | 336 | 4.0 × 104 [0.2–4.0 × 104] | 133 | 39.6 | n.a | 7 | 68 | 17 |
Total | 96 | 2'357 | 1'107 | 142 | 39 |
