Table 2 Reasons leading to the euthanasia.

From: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies

Infectious agent (n)

Reason of euthanasia

Weight score = 3, n (%)*

Clinical score ≥ 6, n (%)*

  

Weight score (0–3) used to calculate clinical score, n (%)

0

1

2

3

L. monocytogenes (216)

30 (13.9)

186 (86.1)

0 (0.0)

5 (2.7)

80 (43.0)

101 (54.3)

S. pneumoniae (107)

1 (0.6)

106 (99.4)

1 (0.9)

3 (2.8)

101 (95.3)

1 (0.9)

H1N1 (77)

9 (11.7)

68 (88.3)

0 (0.0)

1 (1.5)

29 (42.6)

38 (55.9)

  1. Data were collected from euthanized mice in cohort 2. Mice that died between two monitoring (mainly during the night) were not considered.
  2. *Weight score = 3: the weight loss limit for euthanasia (3) was reached while the total clinical score was < 6. Clinical score ≥ 6: the clinical score limit for euthanasia (6) was reached while the weight loss score was ≤ 3.
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