Table 3 Calculation of the impact of weight loss threshold on the mortality rate linked to an increase in euthanasia.
From: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies
Model of infection (total mice used, observed mortality in %) | Minimum weight loss (%) leading to euthanasia1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
25% | 20% | 15% | 10% | |||||||||
Additional deaths (n) | Death rate (%) | p value* | Additional deaths (n) | Death rate (%) | p value | Additional deaths (n) | Death rate (%) | p value | Additional deaths (n) | Death rate (%) | p value | |
C. albicans (252, 34.9%) | 33 | 48.0 | < 0.001 | 61 | 59.1 | < 0.001 | 99 | 74.2 | < 0.001 | 132 | 87.3 | < 0.001 |
L. monocytogenes (1048, 47.0%) | 25 | 49.4 | 0.122 | 79 | 54.6 | < 0.001 | 184 | 64.6 | < 0.001 | 283 | 74.0 | < 0.001 |
S. pneumoniae (721, 54.5%) | 4 | 55.1 | 0.764 | 10 | 55.9 | 0.453 | 22 | 57.6 | 0.097 | 53 | 61.9 | < 0.001 |
H1N1 influenza virus (336, 39.6%) | 45 | 53.0 | < 0.001 | 76 | 62.2 | < 0.001 | 116 | 74.1 | < 0.001 | 150 | 84.2 | < 0.001 |
