Fig.3

Results of MR analysis between IL-6R blockade and CVDs for repeated analysis. Nsnp, number of single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; WME, weighted median; IVW-FE, inverse variance weighted fixed effects; IVW-MRE, inverse variance weighted multiplicative random effects; SM, simple mode; WM, weighted mode. This figure shows the results of the repeated MR analysis after changing the data source of CRP, namely that the IL-6R blockade has a protective effect on CHD and MI, but has no significant effect on HTN, AF and HF. RA is used as a positive control. The IVW method is the primary analysis method. When heterogeneity is detected, the IVW-MRE method is used to reduce bias, otherwise, the IVW-FE method is applied. The MR Egger, WME, SM, and WM serve as supplementary methods. Significance is determined by a Bonferroni-corrected IVW p-values < 0.01 and consistent OR directions across methods. The dots represent the OR values and the line segments represent the 95% confidence intervals, where an OR less than 1 suggests a protective effect of IL-6R blockade, and an OR greater than 1 indicates an increased risk.