Fig. 7 | Scientific Reports

Fig. 7

From: The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway

Fig. 7

The overexpression of SASH1 can inhibit the PI3K-Akt-mTOR signaling pathway. (A), Q-PCR showed successful construction of SASH1 overexpression cells (MDA-MB-231/pcDNA3.1-SASH1). (B), The expression levels of p-Akt, p-PI3K, and p-mTOR were significantly decreased in breast cancer cells of SASH1 overexpression (MDA-MB-231/pcDNA3.1-SASH1). SASH1, SAM—and SH3 domain containing 1; PI3K, phosphoinositide 3-kinase (This study explores PIK3 p110); Akt, protein kinase B (This study explores AKt-Thr308 phosphorylation sites); mTOR, mammalian target of rapamycin (This study explores mTORC1).

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