Fig. 1

Summary of the methodology of this study. First, PWI/DCE images were acquired from UPS patients at baseline (BL), post-chemotherapy (PC), and post-radiation therapy (PRT). Second, tumors were manually contoured in three dimensions by an MD-trained research assistant, generating tumor volume of interest (VOI) segmentations. Third, features were extracted from the tumor VOIs, including morphologic patterns, time-intensity curves, semiquantitative parameters, and radiomics. Finally, statistical analyses were performed on the extracted features comparing responders vs. partial/non-responders.