Fig. 3 | Scientific Reports

Fig. 3

From: Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutation

Fig. 3

Proteome overview of WT and rd10 mice (n = 3 retinas per group). (A) The experimental strategy. Four groups of retinas were separated into two experiments based on age (5w or 8w) and genotype (WT or rd10). (B) Venn diagram showing the overlap of DEPs with p < 0.05 and FC > 2 in retinas at 5w (pink) and 8w (blue). (C) (D) (E) PCA analysis of gross protein differences, and between samples of WT and rd10 at 5w and 8w. (F) Volcano plot indicating 84 upregulated (red) and 138 downregulated (green) proteins in rd10 retinas at 5w (FC > 2, and p < 0.05). (G) Volcano plot showing 120 upregulated (red) and 169 downregulated (green) proteins in rd10 retinas at 8w (FC > 2, and p < 0.05). DEP: differentially expressed protein; PCA: principal component analysis; 5w: 5 weeks; 8w: 8 weeks.

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