Fig. 1

Kaplan-Meier curves and statistical analysis for the association of CRPC progression following ADT with DM or HT in nonmetastatic PC patients. DM (A) and HT (B) were separated into preexisting DM and HT at the initial PC diagnosis (preDM and preHT), newly developed DM and HT after ADT initiation (postDM and postHT), and none of them (nonDM and nonHT), respectively. Statistical differences among and between three patient groups were analyzed using the log-rank test and Cox proportional hazard regression model, respectively. The p values from the log-rank test are given above line graphs, and hazard ratios (HRs) with 95% CIs and p values from the Cox regression analysis are shown in square boxes.