Table 3 Variation of clinical outcomes depending on the appropriateness of changes in antibiotic prescriptions.

From: Impact of antibiotic changes on hospital stay and treatment duration in community-acquired pneumonia

 

At least once inappropriateness* (n = 163)

All-appropriateness† (n = 273)

P-value

Time to clinical stability (days)‡

3.34 ± 2.23

3.12 ± 1.88

0.261

Duration of intravenous antibiotic use (days)‡

8.18 ± 3.57

7.27 ± 3.33

0.007

Duration of oral antibiotic use (days)‡

5.77 ± 4.20

6.60 ± 4.57

0.059

Duration of total antibiotic use (days)‡

13.31 ± 3.44

13.40 ± 4.42

0.823

Length of stay (excluding ER) (days)‡

8.85 ± 3.85

7.84 ± 3.79

0.007

Length of stay (including ER) (days)‡

9.59 ± 3.96

8.45 ± 3.94

0.003

Side effects (%)§

14 (8.3)

15 (5.6)

0.373

  1. ER, emergency room.
  2. *Any of the three antibiotic prescriptions (initial, first change and second change) includes inappropriate prescriptions.
  3. †All three antibiotic prescriptions (initial, first change and second change) are appropriate.
  4. ‡Continuous variables by independent t-test.
  5. §Categorical variables by Chi-square test; Pearson’s Chi-square.
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