Fig. 3 | Scientific Reports

Fig. 3

From: Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction

Fig. 3

(A) Characteristics of module 4 with the significant and highest number of apoptotic proteins are presented. The apoptosis-related proteins and hub-bottlenecks of the SAI network were detected in module 4 which are shown in pink and yellow, respectively. (B) Identification of sub-modules and sub-sub-modules of module 4 up to the last level of the SAI network to trace hub genes and screen driver genes of the apoptosis-related module. The dashed red arrow shows the hubs transmission to the next level. (C) Hub-module interaction analysis shows the crosstalk among module 4 and other top protein modules through apoptosis-related hubs in the SAI network.

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