Table 1 Hub-bottleneck genes of the SAI network and their related information.

TP53

155

0.051

Tumor Protein P53

JUN

113

0.038

Jun Proto-Oncogene, AP-1 Transcription Factor Subunit

AKT1

105

0.035

AKT Serine/Threonine Kinase 1

IL1B

103

0.027

Interleukin 1 Beta

Apoptosis hub-bottleneck genes

MAPK3

100

0.027

Mitogen-Activated Protein Kinase 3

HSP90AA1

98

0.025

Heat Shock Protein 90 Alpha Family Class A Member 1

STAT1

97

0.024

Signal Transducer And Activator Of Transcription 1

TRAF6

85

0.021

TNF Receptor Associated Factor 6

MMP9

80

0.018

Matrix Metallopeptidase 9

MAPK1

77

0.015

Mitogen-Activated Protein Kinase 1

TLR2

75

0.014

Toll Like Receptor 2

TNF

180

0.067

Tumor Necrosis Factor

CTNNB1

160

0.052

Catenin Beta 1

EGFR

133

0.049

Epidermal Growth Factor Receptor

STAT3

128

0.048

Signal Transducer and Activator of Transcription 3

Non-apoptosis hub-bottleneck genes

IL6

114

0.038

Interleukin 6

ALB

108

0.036

Albumin

FN1

103

0.027

Fibronectin 1

TLR4

95

0.024

Toll Like Receptor 4

PTPRC

91

0.024

Protein Tyrosine Phosphatase Receptor Type C

RELA

89

0.022

RELA Proto-Oncogene, NF-KB Subunit

VEGFA

83

0.02

Vascular Endothelial Growth Factor A

IL10

79

0.017

Interleukin 10

FOS

78

0.017

Fos Proto-Oncogene, AP-1 Transcription Factor Subunit

IL4

77

0.014

Interleukin 4

ITGAM

73

0.013

Integrin Subunit Alpha M

IL2

69

0.013

Interleukin 2

PIK3CA

68

0.013

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha