Table 1 Characteristics of the sample and its cohorts.

From: On the utility of cerebrospinal fluid biomarkers in canine neurological disorders

 

MUO (n = 47)

CM/SM/M (n = 29)

Tumors (n = 19)

Epileptic control (n = 66)

Sex—f/m

25/22

13/16

8/11

26/40

Age—median (range)

8.0 (1.0, 15.5)

5.0 (0.5, 12.0)

11.5 (6.5, 12.5)

6.5 (0.5, 16.0)

Aβ1-42 (pg/mL) (Fig. 1A)

 n

45

27

19

65

 Mean, SD

1597.35 (564.93)

1820.93 (450.04)

1256.29 (305.80)

1833.79 (435.71)

 95% CI

1427.62, 1767.07

1642,90 1998.96

1108.90, 1403.69

1725.82, 1941.75

NfL (pg/mL) Fig. 1B

 n

30

20

18

48

 Mean, SD

21,556.00 (25,169.66)

11,247.10 (15,914.85)

5982.15 (3862.96)

1201.02 (994.89)

 95% CI

12,157.50, 30,954.51

3798.72, 18,695.48

4061.15, 7903.16

912.14, 1489.91

NSE (pg/mL) Fig. 1C

 n

30

21

18

48

 Mean, SD

47.83 (42.84)

46.44 (40.79)

83.23 (48.59)

31.15 (31.33)

 95% CI

31.84, 63.83

27.87, 65.00

59.07, 107.39

22.05, 40.25

Total tau (pg/mL) (Fig. 1D)

 n

45

29

19

65

 Mean, SD

82.92 (67.19)

48.65 (29.68)

68.60 (36.63)

31.45 (10.43)

 95% CI

62.73, 103.10

37.36, 59.94

50.94, 86.25

28.87, 34.04

  1. Aβ1-42 = Amyloid-β1–42; NSE, neuron-specific enolase; NfL, neurofilament-light chain; n, number of dogs or analyzed CSF samples; MUO, Meningoencephalitis of unknown origin; Tumors, brain tumors; CM/SM/M, myelopathies (Chiari malformation, CM; Syringomyelia, SM; Myelitis, M); Epileptic Control, Idiopathic Epilepsy, used as a control group.