Table 1 Toxicity of the pyrrolone derivatives against lab strain of third larval instar of Culex pipiens after 72 h of exposure.

From: Rational design and synthesis of new pyrrolone candidates as prospective insecticidal agents against Culex pipiens L. Larvae

Compd. (µg/mL)

LC25 (aF.l. at 95%)

LC50 (aF.l. at 95%)

LC90 (aF.l. at 95%)

bSlope ± SE

cX2

P

Relative potency

2

9.91

(5.71–14.57)

44.96

(34.41–57.02)

203.78

(150.85–306.72)

1.02 ± 0.10

3.46

0.48

3.17

3

18.25

(11.87–24.93)

79.30

(62.94–101.09)

1292.79

(752.50–2874.53)

1.05 ± 0.11

1.98

0.73

1.79

4

11.65

(6.96–16.74)

51.94

(40.35–65.64)

888.90

(539.58–1852.14)

1.03 ± 0.10

3.80

0.43

2.74

5

8.33

(4.61–12.52)

38.07

(28.60–48.56)

682.70

(424.58–1373.62)

1.02 ± 0.10

5.92

0.20

3.74

6

15.42

(9.73–21.45)

67.70

(53.46–85.79)

1125.42

(665.67–2440.25)

1.04 ± 0.11

3.74

0.44

2.10

7

24.85

(17.39–32.54)

97.74

(78.63–124.32)

1318.79

(788.02–2785.00)

1.13 ± 0.10

3.53

0.47

1.45

8

13.34

(8.15–18.91)

59.87

(46.87–75.84)

1037.40

(616.24–2239.60)

1.03 ± 0.10

3.79

0.43

2.38

9

6.31

(1.35–8.91)

22.81

(9.35–35.15)

262.16

(182.99–951.82)

1.20 ± 0.12

5.22

0.21

6.24

10

6.63

(3.70–9.98)

26.76

(19.74–34.19)

378.53

(258.26–650.68)

1.11 ± 0.11

6.04

0.16

5.32

11

40.79

(30.90–51.04)

142.56

(115.13–183.99)

1536.23

(926.65–3180.37)

1.24 ± 0.12

3.99

0.40

1

12

27.82

(19.83–36.05)

107.53

(86.56–137.46)

1403.08

(835.11–2979.32)

1.14 ± 0.10

3.24

0.51

1.32

13

32.15

(23.36–41.20)

122.49

(98.37–158.23)

1555.80

(915.18–3367.55)

1.16 ± 0.12

4.11

0.39

1.16

14

21.84

(14.89–29.03)

88.65

(71.07–112.55)

1269.85

(756.01–2703.87)

1.10 ± 0.11

3.22

0.52

1.60

15

6.24

(1.38–9.25)

24.39

(10.52–37.72)

324.83

(220.01–1222.15)

1.13 ± 0.11

6.56

0.13

5.84

16

7.66

(4.33–11.41)

32.09

(24.04–40.76)

487.90

(322.01–885.74)

1.08 ± 0.10

7.43

0.10

4.44

17

6.08

(1.59–8.98)

21.05

(9.52–31.67)

222.86

(152.01–649.20)

1.25 ± 0.12

5.52

0.23

6.77

Chlorfenapyr

7.01

(1.55–9.84)

25.43

(10.69–39.69)

293.88

(207.14-1126.99)

1.20 ± 0.12

6.58

0.11

5.60

  1. a(F.l.) Fiducial limits.
  2. bSlope of the concentration-mortality regression line ± standard error.
  3. cX2 chi-square significant at P < 0.05.
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