Fig. 4 | Scientific Reports

Fig. 4

From: RNA-seq and bulk RNA-seq data analysis of cancer-related fibroblasts (CAF) in LUAD to construct a CAF-based risk signature

Fig. 4

Identification of the hub predictive genes for constructing a risk signature. (A) Volcano plot of differentially expressed genes of cancer and normal tissues in TCGA cohort; (B) Univariate Cox regression analysis identified genes related to prognosis as volcano plots; (C) The trajectory of each independent variable with lambda; (D) Plots of the produced coefficient distributions for the logarithmic (lambda) series for parameter selection (lambda); (E) The multivariate Cox coefficients for each genes in the risk signature; (F-K) Multivariate Cox coefficients for each gene in the risk signature; ROC and K-M curves of risk model constructed by 8 genes in GSE3141 (F), GSE31210 (G), GSE37745 (H), GSE50081 (I), GSE68465 (J) and TCGA cohort (K).

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