Table 1 The IC50 values for the inhibitory effects of EV206 on the viability of NSCLC cells, NSCLC cells that are resistant to anticancer drugs, and normal cells.

From: Development of a novel N14-substituted antitumor evodiamine derivative with inhibiting heat shock protein 70 in non-small cell lung cancer

Classification

Cell line

IC50 (µM) (mean ± SD, n = 3)

NSCLC

H1299

0.35 ± 0.16

NSCLC

A549

0.23 ± 0.12

NSCLC

H460

0.31 ± 0.14

NSCLC

H226B

0.38 ± 0.05

NSCLC

PC9

0.46 ± 0.23

NSCLC, drug resistant

H1299/CsR

0.30 ± 0.16

NSCLC, drug resistant

H1299/PmR

0.20 ± 0.05

NSCLC, drug resistant

H460/PcR

0.35 ± 0.21

NSCLC, drug resistant

H226B/PcR

0.30 ± 0.07

NSCLC, drug resistant

PC9/ER

0.46 ± 0.11

Normal cells

RPE

> 0.5 (3.2#)

Normal cells

MLE12

> 0.5 (0.71#)

Normal cells

NCTC 1469

> 0.5 (0.92#)

  1. #The digits in blankets denote the predicted IC50 value, which was determined by an extrapolation method.
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