Table 2 Predicted targets for bioactive compounds in Krishnadi Churna.
No. of symptoms | Bioactive compounds | No. of targets | Targets |
|---|---|---|---|
1 | Resveratrol | 29 | APP, CYP19A1, ABCB1, CA12, CA14, CA9, CYP1A1, CYP1A2, CYP1B1, DPP4, XIAP, EGFR, ESR1, GLO1, MAPT, NFE2L2, ALOX5, PTGS1, PTGS2, PTK2B, NQO2, RELA, TRPA1, TTR TUBB1, TUBB3, TPPP, TYR, LCK |
2 | Gallic acid | 14 | AKR1C3, FUT7, CA1, CA12, CA14, CA2, CA7, CA9, DRD1, EGFR, SERPINE1, GALNT2, TTR, PLAU |
3 | Piperine | 8 | ACHE, MAOA, MAOB, BCHE, HDAC1, SIGMAR1, TRPM8, TRPV1 |
4 | Quercetin | 90 | HSD17B1, HSD17B2, ACHE, ADORA2A, ADORA3, AKR1B1, AKR1C3, SNCA, MAOA, MAOB, AR, CYP19A1, AHR, ABCB1, AURKB, NTRK2, BACE1, ABCG2, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CSNK2A3, CISD1, CDK6, CDK1, CDK2, CDK5R1, CCNT1, CFTR, CYP1A1, CYP1A2, CYP1B1, CYP2D6, OPRD1, DPP4, TOP1, TOP2A, APEX1, DYRK1A, ELAVL3, EGFR, ESR1, ESR2, GSK3B, MET, IP6K2, IGF1R, GLO1, ACP1, GAA, MMP12, MKNK1, MKNK2, KIT, MMP9, NOX4, NR0B1, PSIP1, PPARA, PIK3CG, PGF, PARP1, TNKS, TNKS2, ALOX12, ALOX15, ALOX15B, PTGS1, PTGS2 PSMB1, F2, FLT3, PTPRS, PIM1, TRPC5, SI, TERT, TST, TTR, TYR, LCK, AXL, YES1, PTPN1, VEGFA, KDR, XDH |
5 | Beta-sitosterol | 27 | HMGCR, CRYAA, CRYAB, AR, CYP19A1, NR1H4, F10, DHCR24, ESR1, ESR2, GPR183, GRIN1, GRIN2A, GRIN2B, ITGB3, GAA, RORC, OSBP2, NR1H3, NR1H2, F2, SHBG, CYP17A1, SREBF2, PTPN1, PTPN2, VDR |
6 | Resveratrol + gallic acid | 5 | CA14, CA9, CA12, EGFR, TTR |
7 | Resveratrol + piperine | 0 | |
8 | Resveratrol + quercetin | 15 | CYP19A1, ABCB1, CYP1A1, CYP1A2, CYP1B1, DPP4, ESR1, GLO1, PTGS1, PTGS2, TYR, LCK, CA12, EGFR, TTR |
9 | Resveratrol + beta-sitosterol | 2 | CYP19A1, ESR1 |
10 | Gallic acid + piperine | 0 | |
11 | Gallic acid + quercetin | 6 | AKR1C3, CA2, CA7, CA12, EGFR, TTR |
12 | Gallic acid + beta-sitosterol | 0 | |
13 | Piperine + quercetin | 3 | ACHE, MAOA, MAOB |
14 | Piperine + beta-sitosterol | 0 | |
15 | Quercetin + beta-sitosterol | 7 | AR, CYP19A1, ESR1, ESR2, GAA, F2, PTPN1 |
16 | Resveratrol + gallic acid + piperine | 0 | |
17 | Resveratrol + gallic acid + quercetin | 3 | CA12, EGFR, TTR |
18 | Resveratrol + gallic acid + beta-sitosterol | 0 | |
19 | Resveratrol + piperine + quercetin | 0 | |
20 | Resveratrol + piperine + beta-sitosterol | 0 | |
21 | Resveratrol + quercetin + beta-sitosterol | 2 | CYP19A1, ESR1 |
22 | Gallic acid + piperine + quercetin | 0 | |
23 | Gallic acid + piperine + beta-sitosterol | 0 | |
24 | Gallic acid + quercetin + beta-sitosterol | 0 | |
25 | Piperine + quercetin + betasitosterol | 0 | |
26 | Resveratrol + gallic acid + piperine + quercetin | 0 | |
27 | Resveratrol + piperine + quercetin + beta-sitosterol | 0 | |
28 | Resveratrol + gallic acid + quercetin + beta-sitosterol | 0 | |
28 | Resveratrol + gallic acid + piperine + beta-sitosterol | 0 | |
30 | Gallic acid + piperine + quercetin + beta-sitosterol | 0 | |
31 | Resveratrol + gallic acid + piperine + quercetin + beta-sitosterol | 0 |
