Fig. 3
From: Biochemical rationale for transfusion of high titre COVID-19 convalescent plasma
Immunoglobulin concentration and virus neutralization in CCP samples. (a, b) Bar graphs depicting IgG and IgA concentration. Bar and whiskers represent median and interquartile range. The median value (nM) is depicted next to the vertical dotted line intersecting the x-axis. Statistical significance was calculated by Mann-Whitney test; ****P < 0.0001. (c) Neutralization titres obtained by microneutralization assay (grey) and inhibition ELISA (purple) are depicted in IU/mL in a violin plot. Median (bold font, dashed line) and interquartile values (regular font, dotted line) are depicted in the violin plot. (a-c) Red dots indicate values below the LOD or LOQ. (d) Spearman rank correlation analysis between neutralization and inhibition assay from panel c (n = 55). (e, f) Spearman rank correlation analysis between (e) IgG or (f) IgA concentration and the inhibitory antibody titre (n = 73). Statistical outcome data are given as inserts in the right, bottom corner of each panel.
