Fig. 4
From: Biochemical rationale for transfusion of high titre COVID-19 convalescent plasma
Fractional antibody binding of virus. (a, b) RBD concentrations were derived from reported SARS-CoV-2 RNA data in regular aerosol transmissions and by coughing of a COVID-19 patient (a) or extrapolated from SARS-CoV-2 RNA data found in the respiratory tract of rhesus macaques during peak of infection (b). (c-f) The fraction of RBD bound by IgG (green line) or IgA (blue line) in CCP was calculated for four representative samples in the cohort; (c) high IgG concentration with a high affinity, (d) high IgG concentration with a low affinity, (e) low IgG concentration with a high affinity and (f) low IgA concentration with a high affinity. Binding was modelled during theoretical infection of the CCP donor (open dots, ○), after a single (i.e. 250 mL; open triangles, Δ) or double CCP transfusion in a COVID-19 patient (i.e. 500 mL; open squares, □).
