Fig. 5
From: Biochemical rationale for transfusion of high titre COVID-19 convalescent plasma
Selecting optimal CCP. (a) Simulation of the fraction of antibody bound to virus in clinical trial participants after administration of high (4000 mg, red line) or low dose (1200 mg, green line) REGN-COV (∇). (b) Fraction of antibody bound to virus using CCP from a convalescent, vaccinated CCP donor and (c) a donor with known very high antibody concentration and low Kd23. Data representation is as in Fig. 4. (d) The distribution of CCP samples (n = 74) by IgG concentration and Kd, app or Kd, app1. Colour coded according to arbitrary Kd, app ranges: below 1 nM (high affinity, blue), between 1 and 10 nM (mid affinity, orange) and above 10 nM (low affinity, purple). The green box indicates the CCP samples with a high affinity and high IgG concentration. The dotted lines intersecting the x- and y-axis represent respectively the cut-off at 150 nM IgG and 1 nM Kd, app.
