Fig. 6
From: Integrating holotomography and deep learning for rapid detection of NPM1 mutations in AML
Schematic illustration of the proposed NPM1 mutation screening method in comparison to the gold standard test. The gold standard test provides the confirmatory genetic profile based on DNA next-generation sequencing, yet the typical turnaround time may stretch to 2Â weeks. The proposed method can provide an early screening based on the three-dimensional morphology of myeloblasts using holotomography (HT) imaging aided by statistical and artificial intelligence analyses.
