Fig. 5 | Scientific Reports

Fig. 5

From: Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells

Fig. 5

Whole transcriptome sequencing showed that DCA markedly reduced the expression of oxidative phosphorylation-associated genes in cisplatin-treated mProx cells. mProx cells were treated for 24 h with growth buffer containing cisplatin (0 or 25 µM) in the presence or absence of DCA (10 mM). Total RNA was extracted from the cells used for whole-transcriptome sequencing. Significant differential expression of oxidative phosphorylation-associated genes (n = 114) was detected in mProx cells subjected to different treatments (n = 3 per group) (P < 0.05 and q value < 0.05, one-way ANOVA). The heat map shows the scaled average expression of the detected genes. Blue and yellow colors indicate low and high expression, respectively.

Back to article page