Table 3 The multivariable associations between infant characteristics and the dosing-measured weights percent difference*.

From: Factors influencing the determination of dosing weight in the neonatal intensive care unit (NICU)

Infant characteristics

Dosing - Measured Weight% difference

(95% Confidence Interval) **

p-value

Intubation

-1.0 (-2.1, 0.1)

0.076

Highest creatinine, mg/dL

-5.4 (-7.2, -3.7)

< 0.001

3DMA of daily fluid intake, 10mL/kg/day

0.1 (-0.03, 0.2)

0.138

3DMA of daily urine output, mL/kg/hour

0.8 (0.6, 0.9)

< 0.001

Intercept**

-4.2 (-4.8, -3.5)

< 0.001

  1. 3DMA, 3-day moving average
  2. *Mixed effects linear regression reported as beta coefficient (percent difference), 95th % confidence interval, and p-value
  3. ** Final model predicting Dosing-Measured Weights Difference = [-4.2] + [-5.4*X1] + [0.8*X2]) where X1is the highest creatinine referent to an infant to 1 mg/dL and X2is the 3DMA of urine output referent to 2mL/kg/hr.
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