Table 6 The multivariable association between infant characteristic and the dosing-measured weights percent difference limited to dosing weight changes*.

From: Factors influencing the determination of dosing weight in the neonatal intensive care unit (NICU)

Infant characteristics

Dosing - Measured Weight% difference

(95% Confidence Interval) **

p-value

Patent ductus arteriosus

0.7 (-0.1, 1.4)

0.080

Necrotizing enterocolitis or spontaneous intestinal perforation

-0.6 (-1.4, 0.2)

0.120

Highest creatinine in mg/dL

-3.5 (-4.6, -2.4)

< 0.001

Lowest sodium in mEq/L

0.1 (-0.01, 0.1)

0.070

3DMA of daily fluid intake in 10mL/kg/day

0.4 (0.2, 0.5)

< 0.001

Intercept**

-1.3 (-1.8, -0.9)

< 0.001

  1. 3DMA, 3-day moving average
  2. *Mixed effects linear regression reported as beta coefficient (percent difference), 95th % confidence interval, and p-value
  3. ** Final model predicting Dosing-Measured Weights Difference = [-1.3] + [-3.5*X1] + [0.4*X2]) where X1is the highest creatinine referent to an infant to 1 mg/dL and X2is the 3DMA of fluid intake referent to 140mL/kg
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