Table 3 Multivariate logistic regression analysis of factors associated with transfer to ICU.

	Univariate analysis			Multivariate analysis
	OR	95% CI	P-value	OR	95% CI	P-value
Age	0.994	0.991–0.997	< 0.001	0.996	0.992-1.000	0.048
Male sex	0.795	0.726–0.870	< 0.001	0.810	0.720–0.911	< 0.001
BMI	1.009	0.998–1.019	0.108
Score
SOFA score*	1.248	1.228–1.270	< 0.001
NEWS2 score*	1.178	1.161–1.196	< 0.001
MEWS score	1.253	1.226–1.279	< 0.001	1.225	1.185–1.266	< 0.001
Vital sign
MBP	0.995	0.994–0.997	< 0.001
HR	1.003	1.002–1.005	< 0.001	0.997	0.994–0.999	0.012
RR	1.020	1.014–1.026	< 0.001
Underlying disease
Solid tumor	0.762	0.695–0.836	< 0.001	0.707	0.624–0.802	< 0.001
Hematologic malignancy	1.206	1.052–1.383	0.007	0.847	0.704–1.020	0.080
Chronic lung disease	0.782	0.688–0.888	< 0.001	0.765	0.644–0.908	0.002
Chronic heart disease	1.232	1.113–1.363	< 0.001
Cerebrovascular disease	0.958	0.832–1.104	0.556
Chronic kidney disease	1.192	1.037–1.369	0.013
Diabetes	1.069	0.970–1.179	0.178
Transplantation	1.450	1.171–1.796	0.001
Laboratory findings
pH	0.029	0.019–0.044	< 0.001	0.070	0.037–0.132	< 0.001
P/F ratio	0.997	0.996–0.997	< 0.001	0.997	0.996–0.997	< 0.001
WBC	1.006	1.002–1.009	0.003
Hb	0.975	0.956–0.995	0.014
Platelet	0.999	0.999-1.000	0.001
T-bilirubin	1.026	1.016–1.037	< 0.001	1.017	1.004–1.030	0.012
Creatinine	1.110	1.081–1.140	< 0.001	1.071	1.034–1.110	< 0.001
Lactate	1.163	1.141–1.185	< 0.001	1.113	1.086–1.141	< 0.001
CRP	1.004	0.999–1.010	0.124
Hospitalization time prior to RRT activation	1.008	1.006–1.010	< 0.001	1.004	1.001–1.007	0.013

ICU, intensive care unit; OR, Odds ratio; CI, Confidence interval; BMI, body mass index; SOFA, sequential organ failure assessment; NEWS, national early warning score; MBP, Mean blood pressure; HR, heart rate; RR, respiratory rate; WBC, white blood cell; Hb, hemoglobin; C-reactive protein.
*Spearman correlation analysis between the MEWS and NEWS2 scores showed a high correlation (rho = 0.695, P < 0.001), also SOFA score and creatinine showed a moderate correlation (rho = 429, P < 0.001). Based on this correlation, the SOFA and NEWS2 score was excluded from further analysis.

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