Table 4 Multivariate cox regression analysis of factors associated with 28 day mortality.

From: Characteristics and outcomes of patients screened by the rapid response team and transferred to intensive care unit in South Korea

 

Univariate analysis

Multivariate analysis

OR

95% CI

P-value

OR

95% CI

P-value

Age

1.000

0.997–1.003

0.894

   

Male sex

0.886

0.803–0.978

0.016

   

BMI

1.010

0.998–1.021

0.093

   

Score

      

 SOFA score*

1.181

1.165–1.198

< 0.001

   

 NEWS2 score*

1.128

1.112–1.146

< 0.001

   

 MEWS score

1.145

1.122–1.169

< 0.001

   

Vital sign

      

 MBP

0.995

0.993–0.997

< 0.001

   

 HR

1.001

1.000–1.003

0.082

   

 RR

1.011

1.004–1.017

0.001

1.010

1.002–1.018

0.011

Underlying disease

      

 Solid tumor

1.373

1.246–1.512

< 0.001

1.464

1.283–1.671

< 0.001

 Hematologic malignancy

1.800

1.590–2.039

< 0.001

1.547

1.292–1.853

< 0.001

 Chronic lung disease

1.047

0.916–1.196

0.503

   

 Chronic heart disease

1.007

0.901–1.125

0.902

   

 Cerebrovascular disease

0.719

0.605–0.855

< 0.001

   

 Chronic kidney disease

0.942

0.806–1.100

0.448

   

 Diabetes

0.910

0.816–1.014

0.087

   

Transplantation

0.945

0.743–1.202

0.645

   

Laboratory findings

      

  pH

0.051

0.036–0.072

< 0.001

0.369

0.216–0.631

< 0.001

 P/F ratio

0.997

0.997–0.998

< 0.001

0.998

0.997–0.998

< 0.001

 WBC

1.006

1.004–1.009

< 0.001

1.004

1.002–1.007

< 0.001

 Hb

0.922

0.901–0.943

< 0.001

   

 Platelet

0.997

0.997–0.997

< 0.001

0.998

0.997–0.999

< 0.001

 T-bilirubin

1.048

1.041–1.054

< 0.001

1.042

1.033–1.051

< 0.001

 Creatinine

1.031

1.006–1.057

0.016

   

 Lactate

1.147

1.135–1.159

< 0.001

1.113

1.095–1.132

< 0.001

 CRP

1.021

1.016–1.026

< 0.001

1.026

1.019–1.033

< 0.001

ICU transfer after RRT activation

1.735

1.577–1.909

< 0.001

1.177

1.032–1.342

0.015

Hospitalization time prior to RRT activation

1.007

1.005–1.009

< 0.001

1.005

1.002–1.007

< 0.001

  1. ICU, intensive care unit; OR, Odds ratio; CI, Confidence interval; BMI, body mass index; SOFA, sequential organ failure assessment; NEWS, national early warning score; MBP, Mean blood pressure; HR, heart rate; RR, respiratory rate; WBC, white blood cell; Hb, hemoglobin; C-reactive protein.
  2. *Spearman correlation analysis between the MEWS and NEWS2 scores showed a high correlation (rho = 0.695, P < 0.001), also SOFA score and creatinine showed a moderate correlation (rho = 429, P < 0.001). Based on this correlation, the SOFA and NEWS2 score was excluded from further analysis.
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