Table 4 Comparison of intrathoracic deposition predicted by computational fluid dynamics (CFD), and rapid deposition analysis (RDA) for 20 studies on airway geometries of real patients. API: active pharmaceutical ingredients, % DD: percentage of delivered dose, accuracy is calculated as the absolute difference between RDA and CFD predicted values divided by the CFD values and multiplied by 100 then subtract the results by 100.
From: Rapid deposition analysis of inhaled aerosols in human airways
Device/API | CFD Deposition [% DD] | RDA Deposition [% DD] | Accuracy of RDA compared to CFD |
|---|---|---|---|
Nexthaler_ICS | 24.64 ± 5.05 | 27.01 ± 2.30 | 97.0% |
Nexthaler_LABA | 26.24 ± 5.39 | 28.81 ± 2.45 | 95.5% |
Ellipta_ICS | 14.91 ± 5.23 | 14.69 ± 1.04 | 90.7% |
Ellipta_LABA | 26.34 ± 6.58 | 27.61 ± 1.94 | 88.2% |
Turbohaler_ICS | 41.36 ± 7.59 | 35.55 ± 2.49 | 94.2% |
Turbohaler_LABA | 42.03 ± 7.82 | 36.02 ± 2.52 | 93.5% |
Inhub_ICS | 17.40 ± 3.42 | 14.66 ± 1.22 | 96.8% |
Inhub_LABA | 20.16 ± 3.80 | 17.26 ± 1.43 | 94.1% |
SPECT | 65.33 ± 3.91 | 65.43 ± 4.99 | 99.8% |
eFlow_FormulA | 51.60 ± 1.57 | 61.19 ± 3.57 | 85.2% |
eFlow_FormulC | 52.14 ± 1.39 | 62.53 ± 3.36 | 84.0% |
Zirela | 40.01 ± 12.69 | 42.61 ± 4.76 | 96.8% |
Symbicort_slow | 68.94 ± 5.23 | 61.09 ± 2.75 | 88.8% |
Symbicort_fast | 61.97 ± 7.23 | 52.14 ± 2.35 | 89.1% |
Fostair_ICS | 40.81 ± 1.27 | 37.34 ± 1.35 | 89.0% |
Fostair_LABA | 39.66 ± 1.16 | 35.69 ± 1.29 | 88.4% |
Test_MDI | 49.44 ± 3.38 | 48.63 ± 2.19 | 90.4% |
Trimbow_ICS | 34.03 ± 5.35 | 36.57 ± 1.39 | 96.5% |
Trimbow_LABA | 34.82 ± 5.48 | 37.53 ± 1.42 | 96.1% |
Trimbow_LAMA | 33.24 ± 5.23 | 35.61 ± 1.35 | 96.8% |
