Fig. 1
( A) Axial T1-weighted slice of the brain of a healthy participant corresponding to the center of the 3D CEST volume (slice 4). The same T1-weighted axial image with overlayed, ( B) segmented gray matter (blue), white matter (red), and cerebrospinal fluid (yellow) regions of interest; ( C) amine/amide concentration independent detect (AACID) thresholded contrast map; ( D) Amide* thresholded contrast map; ( E)\(\:{\text{M}\text{T}\text{R}}_{\text{R}\text{e}\text{x}}\left({{\updelta\:}}_{\text{a}\text{m}\text{i}\text{d}\text{e}}\right)\:\)thresholded contrast map, and (F)\(\:{\text{M}\text{T}\text{R}}_{\text{R}\text{e}\text{x}}\left({{\updelta\:}}_{\text{N}\text{O}\text{E}}\right)\:\)thresholded contrast map.
