Fig. 6

Clonal architectures and evolutionary paths are largely shared by matching tumors and organoids. Clonal analysis of organoids and tumors revealed that mutations were frequently shared between them but some appeared to be organoid or tumor-specific. For each patient, a colored bar represents the tumor and organoid trajectories, and the number of mutations was independently scaled by its length. The founding clone names are marked with asterisks and driver genes mutated with non-synonymous small mutations are labeled next to the bar. Individual patients are indicated by S and number while Organoid or Tumor are indicated by O or T respectively (i.e. S2_O: organoid of patient S2). (A) Patient S2. (B) Patient S4. (C) Patient S5. (D) Patient S6. (E) Patient S11. (F) Patient S13 (FOLFIRINOX-treated). (G) Patient S14 (FOLFIRINOX-treated). (H) Patient S16 (FOLFIRINOX-treated). (I) Patient S17 (FOLFIRINOX-treated). (J) Patient S20 (FOLFIRINOX-treated).